You'll be able to notice the difference immediately after activation. I personally prefer to use FeedBro (an RSS reader) to consume most of my data. I don't use twitter or even hardly browse much of the website but when I do I recommend this plugin:
My favorite checkbox on settings are:
- Add “Add muted word” to the “More” menu
- Don't use Chirp font
- Twitter Blue verified checkmarks = Hide
- Reduced interaction mode
- Hiding most of the menu items
It didn't take me long to setup and what I did to test each setting was use my 2nd monitor and just toggle boxes on and off while seeing the changes to see if I like things… MOST of the changes enabled by default are very nice.